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CaO–SiO2–P_2O5体系生物玻璃微球在骨修复材料领域具有应用前景。适量铈离子可赋予生物玻璃抗氧化、抗炎、促血管生成等功能特性。通过喷雾干燥法制备了不同铈离子含量的生物玻璃(Ce–BG)微球粉体材料，研究了Ce含量对Ce–BG微球的物相组成、降解性能以及体外生物活性的影响。结果表明：Ce–BG微球表面光滑，球形度高，元素分布均匀；BG微球中添加Ce会生成CePO4及CeO2相，且随Ce含量提高，Ce–BG微球降解速率变慢，降解产物引起环境pH值升高逐渐减缓。Ce与Ce+Ca的摩尔比为0.03:1.00的Ce–BG微球浸泡在Tris-HCl缓冲液中7 d后pH值最低。不同Ce含量的Ce–BG微球都具有良好的体外诱导磷灰石沉积的能力。
Abstract：Bioglass (BG) microspheres with a constitution of CaO–SiO2–P_2O5 demonstrate promising applications in bone repair.It has been proved that the cerium ion incorporation in bioglass structure can provide materials with additional antioxidant,anti-inflammatory and angiogenesis functions.In this study,cerium-incorporated bioglass (Ce–BG) microspheres were prepared via a spray drying process.The effects of Ce content on the phase composition,degradation performance and in vitro bioactivity of Ce–BG microspheres were investigated.The results show that all microspheres are uniform in element distribution with relatively smooth surfaces and a high degree of sphericity.The Ce incorporation introduces a small amount of CePO4 and CeO2 crystalline phases.Along with the increase of Ce content,the degradation rate of Ce–BG microspheres slows down,and the effect of degradation products on the increase of environmental pH value is alleviated,and the pH value was found to be the lowest after 7 d of immersion for Ce–BG microspheres with mole ratio of Ce and Ce+Ca of 0.03:1.00 in Tris-HCl buffer.Ce–BG microspheres with different Ce content have good ability to induce apatite deposition in vitro.
[1] FILIP D G, SURDU V A, PADURARU A V, et al. Current development in biomaterials-hydroxyapatite and bioglass for applications in biomedical field:A review[J]. J Funct Biomater, 2022,13(4):248.
[2] LI J F, LI J Y, WEI Y H, et al. Ion release behavior of vanadium-doped mesoporous bioactive glass particles and the effect of the released ions on osteogenic differentiation of BMSCs via the FAK/MAPK signaling pathway[J]. J Mater Chem B, 2021, 9(37):7848–7865.
[3] SHI M, ZHAO F J, SUN L Y, et al. Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis[J]. Mater Sci Eng C Mater Biol Appl, 2021, 124:112077.
[4] CIRALDO F E, SCHNEPF K, GOLDMANN W H, et al. Development and characterization of bioactive glass containing composite coatings with ion releasing function for antibiotic-free antibacterial surgical sutures[J]. Materials, 2019, 12(3):423.
[5] ZHENG K, TORRE E, BARI A, et al. Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities[J]. Mater Today Bio, 2020, 5:100041.
[6] DELIORMANL A M. Synthesis and characterization of cerium-and gallium-containing borate bioactive glass scaffolds for bone tissue engineering[J]. J Mater Sci Mater Med, 2015, 26(2):1–13.
[7] MALAVASI G, SALVATORI R, ZAMBON A, et al. Cytocompatibility of potential bioactive cerium-doped glasses based on 45S5[J].Materials, 2019, 12(4):594.
[8] NOURMOHAMMADI E, KHOSHDEL-SARKARIZI H,NEDAEINIA R, et al. Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line[J]. J Cell Physiol, 2019,234(4):4987–4996.
[9] XIANG J Y, LI J M, HE J, et al. Cerium oxide nanoparticle modified scaffold interface enhances vascularization of bone grafts by activating calcium channel of mesenchymal stem cells[J]. ACS Appl Mater Interfaces, 2016, 8(7):4489–4499.
[10] ZAMBON A, MALAVASI G, PALLINI A, et al. Cerium containing bioactive glasses:A review[J]. ACS Biomater Sci Eng, 2021, 7(9):4388–4401.
[11] WERS E, OUDADESSE H, LEFEUVRE B, et al. Excess entropy and thermal behavior of Cu-and Ti-doped bioactive glasses[J]. J Therm Anal Calorim, 2014, 117(2):579–588.
[12] MEZAHI F Z, GIROT A L, OUDADESSE H, et al. Reactivity kinetics of 52S4 glass in the quaternary system SiO2?CaO?Na2O?P2O5:Influence of the synthesis process:Melting versus sol?gel[J]. J Non Cryst Solids, 2013, 361:111–118.
[13] DESHMUKH K, KOVá?íK T, K?ENEK T, et al. Recent advances and future perspectives of sol?gel derived porous bioactive glasses:A review[J]. RSC Adv, 2020, 10(56):33782–33835.
[14] DURGALAKSHMI D, RAKKESH R A, ARUNA P, et al. Bioactivity and hemocompatibility of sol?gel bioactive glass synthesized under different catalytic conditions[J]. New J Chem, 2020, 44(48):21026–21037.
[15] ZHENG K, BOCCACCINI A R. Sol?gel processing of bioactive glass nanoparticles:A review[J]. Adv Colloid Interface Sci, 2017, 249:363–373.
[16] CHEN X F, MENG Y C, LI Y L, et al. Investigation on bio-mineralization of melt and sol?gel derived bioactive glasses[J].Appl Surf Sci, 2008, 255(2):562–564.
[17] CHOU Y J, HSIAO C W, TSOU N T, et al. Preparation and in vitro bioactivity of micron-sized bioactive glass particles using spray drying method[J]. Appl Sci, 2018, 9(1):19.
[18] MOLINO G, BARI A, BAINO F, et al. Electrophoretic deposition of spray-dried Sr-containing mesoporous bioactive glass spheres on glass?ceramic scaffolds for bone tissue regeneration[J]. J Mater Sci,2017, 52(15):9103–9114.
[19]胡亚萍,田正芳,朱敏,等.喷雾干燥可控制备生物玻璃微球及其体外生物活性研究[J].无机材料学报, 2020, 35(11):1268–1276.HU Yaping, TIAN Zhengfang, ZHU Min, et al. J Inorg Mater(in Chinese), 2020, 35(11):1268–1276.
[20] KOKUBO T, TAKADAMA H. How useful is SBF in predicting in vivo bone bioactivity?[J]. Biomaterials, 2006, 27(15):2907–2915.
[21] LI H Y, WANG Z L, SONG Q X, et al. Polyetheretherketone microspheres loaded with cerium dioxide nanoparticles mitigate damage from cellular oxidative stress and promote bone repair[J].Mater Des, 2023, 225:111426.
[22] FRANCHINI M, LUSVARDI G, MALAVASI G, et al. Galliumcontaining phospho-silicate glasses:Synthesis and in vitro bioactivity[J]. Mater Sci Eng C, 2012, 32(6):1401–1406.
基本信息:
DOI：10.14062/j.issn.0454-5648.20230189
中图分类号:R318.08;TQ171.7
引用信息:
[1]陈宝龙,胡亚萍,朱敏,等.喷雾干燥法制备含铈生物玻璃微球及其体外生物活性[J].硅酸盐学报,2023,51(10):2527-2535.DOI:10.14062/j.issn.0454-5648.20230189.
基金信息:
国家自然科学基金(52072246)
2023-08-04
2023-08-04
2023-08-04