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凹凸棒石是一种具有2:1型链层状结构的硅酸盐黏土矿物，针棒状的晶体长度约为0.5～5.0μm，是一种不可再生的天然纳米材料。凹凸棒石特殊的结构赋予了它优异的吸附性，胶体性等性质。凹凸棒石作为绿色的天然矿物材料，具有良好的生物相容性，并且储量丰富，价格低廉，所以在生物医药领域有着广泛的应用潜力。本文综述了凹凸棒石在生物抗菌、药物输送、骨组织工程、伤口敷料等方面的应用研究进展，并对其未来的应用前景进行了展望。本文对于凹凸棒石的生物医学应用研究具有重要的参考价值。
Abstract：Attapulgite is a rod like silicate clay minerals with a 2:1 type chain layered nanostructure, and the length of rod crystal is 0.5–5.0 μm. It is a non-renewable natural nanomaterial. The layered crystal structure of the attapulgite chain endows it with special physical and chemical properties, including adsorption, colloidal, and cation exchange properties. Attapulgite is widely used in agriculture, environmental protection, chemical industry, and other fields due to its superior properties. The breakthrough in key common technologies for the dissociation of crystal beams in palygorskite rods enables the expansion of palygorskite from conventional applications to high-tech applications. Attapulgite as a non-toxic natural mineral material has good biocompatibility, abundant reserves, and low price. It has an enormous application potential in the field of high value-added biopharmaceuticals. This review summarized recent research work on the application, the structure and properties of attapulgite. The first part summarized the research progress of the application of attapulgite in the field of biological antibacterial, elaborated on the possible antibacterial mechanisms of attapulgite composite antibacterial materials, compared the preparation methods and antibacterial properties of different attapulgite based composite antibacterial materials, and gave that one of the research hotspots for attapulgite based composite antibacterial materials is to explore a simple and green preparation method. The second part summarized the application of attapulgite in the field of feed additives, represented the preparation of three different attapulgite based feed additives and their respective advantages and disadvantages, and pointed out that the relevant products are used in production practice, and listed some typical production process diagrams of the products. The third part represented the application of palygorskite in drug carriers. Attapulgite based drug carriers are mainly in the form of hydrogels and nanofibers. At present, there is no research on the application of attapulgite based drug carriers in vivo. The main reason is that the safety of palygorskite in vivo is unknown, and it is also stable, making it difficult to enter the blood and urinary circulation system as a drug carrier. However, the prepared attapulgite sustained-release tablets can be discharged through the digestive system and have great application prospects. The fourth part represented the application of attapulgite in composite scaffold materials. Although attapulgite based composite scaffold materials have a good osteogenic induction in vitro, their osteogenic induction in vivo is still unclear, and the mechanism of osteogenic induction in vitro is still unclear. The fifth part summarized the application of attapulgite in wound healing. Attapulgite based wound dressings have a good usability. Mixed dimensional attapulgite seems to have better usage effects and is expected to become a novel generation of hemostatic materials. Summary and prospects 1) In the future, it is necessary to accelerate the technological research on the full dispersion of attapulgite single crystals. Also, there is still a room for progress in the surface modification technology of attapulgite based composite antibacterial materials. The more attention should be paid to green and simple physical modification technologies, which can improve the production efficiency, and reduce the environmental pollution and costs. 2) Further research should be conducted on the application of palygorskite as a drug carrier on the body surface and digestive system, and pathways and methods suitable should be found to enable palygorskite to undergo harmless degradation in the blood and urinary systems. 3) It is necessary to accelerate the research on surface modification technologies of palygorskite, and make palygorskite based wound dressings into a form similar to gauze, which can to some extent reduce the risk of its entry into the blood system. 4) The practical application of attapulgite in the field of biomedicine is still relatively limited. In the future, we should accelerate the clinical research of attapulgite in the field of biomedicine, while still expanding the research of attapulgite in the field of biomedicine practice. For instance, we could use attapulgite to adsorb the metabolite of cholesterol-bile acid-to treat hypertension and hyperlipidemia. The adsorption of palygorskite is used to regulate the intestinal flora and interfere with the occurrence of type 2 diabetes. It is possible for the treatment of tumors to utilize the stability and biocompatibility of attapulgite to prepare high-performance drug loaded microspheres for embolization. The antibacterial and biocompatibility of attapulgite are also utilized to prepare alternative products for orthopedics and dentistry. This review provided a reference for the application research of attapulgite in the field of biomedicine.
[1] BONDAREV A, ZHILYAKOVA E, BONDAREVA N, et al.Classification and systematics of medical clay[C]//Proceedings of the1st International Symposium Innovations in Life Sciences(ISILS2019). Belgorod, Russian Federation. Paris, France:Atlantis Press,2019:146–148.
[2] KANOULAS V, PAPADOPOULOS G A, ARSENOS G, et al. Effects of attapulgite dietary supplementation on sow performance in two commercial farms in Greece[J]. J Hellenic Vet Med Soc, 2018, 68(2):193.
[3] SKOUFOS I, GIANNENAS I, TONTIS D, et al. Effects of oregano essential oil and attapulgite on growth performance, intestinal microbiota and morphometry in broilers[J]. SA J An Sci, 2016, 46(1):77.
[4] NING Y, QIN W, REN Y H, et al. Effect of icariin/attapulgite/collagen typeⅠ/polycaprolactone composite scaffold in repair of rabbit tibia defect[J]. Chinese Journal of Reparative and Reconstructive Surgery,2019, 33(9):1181–1189.
[5] WANG W B, WANG A Q. Recent progress in dispersion of palygorskite crystal bundles for nanocomposites[J]. Appl Clay Sci,2016, 119:18–30.
[6]郭朝先,石博涵.中国医药产业国际竞争力评估与“十四五”时期高质量发展对策[J].北京工业大学学报(社会科学版), 2021, 21(3):65–79.GUO Chaoxian, SHI Bohan. J Beijing Univ Technol:Soc Sci Ed, 2021,21(3):65–79.
[7] CUI M K, MU P, SHEN Y Q, et al. Three-dimensional attapulgite with sandwich-like architecture used for multifunctional water remediation[J]. Sep Purif Technol, 2020, 235:116210.
[8] WANG W B, WANG A Q. Palygorskite nanomaterials:Structure,properties, and functional applications[M]//Nanomaterials from Clay Minerals. Amsterdam:Elsevier, 2019:21–133.
[9] Bradley W. The structural scheme of attapulgite[J]. Am Mineralogist:J Earth Planetary Mater, 1940, 25(6):405–410.
[10] WANG W B, MU B, ZHANG J P, et al. Attapulgite:From clay minerals to functional materials[J]. Sci Sin-Chim, 2018, 48(12):1432–1451.
[11] RHOUTA B, ZATILE E, BOUNA L, et al. Comprehensive physicochemical study of dioctahedral palygorskite-rich clay from Marrakech High Atlas(Morocco)[J]. Phys Chem Miner, 2013, 40(5):411–424.
[12]王爱勤,卢予沈,牟斌,等.混维凹凸棒石黏土全矿物利用研究现状与展望[J].科学通报, 2022, 67(增刊2):3411–3424.WANG Aiqin, LU Yushen,(MOU/MU)Bin, et al. Chin Sci Bull, 2022,67(Suppl 2):3411–3424.
[13] WANG W B, WANG A Q. Nanoscale clay minerals for functional ecomaterials:Fabrication, applications, and future trends[J]. Handbook Ecomater, 2019, 2019:2409–2490.
[14] HADEN W, SCHWINT I A. Attapulgite:Its properties and applications[J]. Ind Eng Chem, 1967, 59:58–69.
[15] DUAN Z H, ZHAO Q N, WANG S, et al. Novel application of attapulgite on high performance and low-cost humidity sensors[J].Sens Actuat B Chem, 2020, 305:127534.
[16] PANDA B, RUAN S Q, UNLUER C, et al. Improving the 3D printability of high volume fly ash mixtures via the use of nano attapulgite clay[J]. Compos Part B Eng, 2019, 165:75–83.
[17]王钰轩,俄胜哲,袁金华,等.凹凸棒石在农业及环境领域的研究现状及进展[J].磷肥与复肥, 2021, 36(4):42–48.WANG Yuxuan, E Shengzhe, YUAN Jinhua, et al. Phosphate Compd Fertil, 2021, 36(4):42–48.
[18] WANG H, WANG X J, MA J X, et al. Removal of cadmium(II)from aqueous solution:A comparative study of raw attapulgite clay and a reusable waste-struvite/attapulgite obtained from nutrient-rich wastewater[J]. J Hazard Mater, 2017, 329:66–76.
[19] LI X Y, ZHANG D Y, LIU X Q, et al. A tandem demetalization–desilication strategy to enhance the porosity of attapulgite for adsorption and catalysis[J]. Chem Eng Sci, 2016, 141:184–194.
[20] YANG F F, WANG A Q. Recent researches on antimicrobial nanocomposite and hybrid materials based on sepiolite and palygorskite[J]. Appl Clay Sci, 2022, 219:106454.
[21] CAI X, ZHANG J L, OUYANG Y, et al. Bacteria-adsorbed palygorskite stabilizes the quaternary phosphonium salt with specific-targeting capability, long-term antibacterial activity, and lower cytotoxicity[J]. Langmuir, 2013, 29(17):5279–5285.
[22]王爱勤,王文波,郑易安.凹凸棒石棒晶束解离及其纳米功能复合材料[M].北京:科学出版社, 2014.WANG Aiqin, WANG Wenbo, ZHENG Yian. Dissociation of attapulgite rod crystal beam and its nano-functional composites[M].Beijing:Science Press, 2014.
[23] HUO C L, YANG H M. Synthesis and characterization of ZnO/palygorskite[J]. Appl Clay Sci, 2010, 50(3):362–366.
[24] HUI A P, YAN R, WANG W B, et al. Incorporation of quaternary ammonium chitooligosaccharides on Zn O/palygorskite nanocomposites for enhancing antibacterial activities[J]. Carbohydr Polym, 2020, 247:116685.
[25] ARAúJO C M, DAS VIRGENS SANTANA M, DO NASCIMENTO CAVALCANTE A, et al. Cashew-gum-based silver nanoparticles and palygorskite as green nanocomposites for antibacterial applications[J].Mater Sci Eng C Mater Biol Appl, 2020, 115:110927.
[26] HAN S, ZHANG H, KANG L W, et al. A convenient ultraviolet irradiation technique for synthesis of antibacterial Ag-pal nanocomposite[J]. Nanoscale Res Lett, 2016, 11(1):431.
[27] DONSìF, FERRARI G. Essential oil nanoemulsions as antimicrobial agents in food[J]. J Biotechnol, 2016, 233:106–120.
[28] WU Y P, LUO Y G, ZHOU B, et al. Porous metal-organic framework(MOF)Carrier for incorporation of volatile antimicrobial essential oil[J]. Food Control, 2019, 98:174?178.
[29] LEI H, WEI Q N, WANG Q, et al. Characterization of ginger essential oil/palygorskite composite(GEO–PGS)and its anti-bacteria activity[J].Mater Sci Eng C Mater Biol Appl, 2017, 73:381–387.
[30] ZHONG H Q, MU B, YAN P J, et al. A comparative study on surface/interface mechanism and antibacterial properties of different hybrid materials prepared with essential oils active ingredients and palygorskite[J]. Colloids and Surfaces A:Physicochemical and Engineering Aspects, 2021, 618:126455.
[31]农业农村部.中华人民共和国农业农村部公告第194号[J].中华人民共和国农业农村部公报, 2019(7):126.Ministry of agriculture and rural affairs. Gaz Minist Agric Rural Aff People’s Repub China, 2019(7):126.
[32] BAMPIDIS V A, CHRISTODOULOU V, THEOPHILOU N, et al.Effect of dietary palygorskite on performance and blood parameters of lactating Holstein cows[J]. Appl Clay Sci, 2014, 91–92:25–29.
[33] CHEN Y P, CHENG Y F, LI X H, et al. Dietary palygorskite supplementation improves immunity, oxidative status, intestinal integrity, and barrier function of broilers at early age[J]. Anim Feed Sci Technol, 2016, 219:200–209.
[34] CHEN Y P, CHENG Y F, YANG W L, et al. An evaluation of palygorskite inclusion on the growth performance and digestive function of broilers[J]. Appl Clay Sci, 2016, 129:1–6.
[35] QIAO L, CHEN Y P, WEN C, et al. Effects of natural and heat modified palygorskite supplementation on the laying performance, egg quality, intestinal morphology, digestive enzyme activity and pancreatic enzyme mRNA expression of laying hens[J]. Appl Clay Sci,2015, 104:303–308.
[36] ZHANG N, HAN X Y, ZHAO Y, et al. Removal of aflatoxin B1 and Zearalenone by clay mineral materials:In the animal industry and environment[J]. Applied Clay Science, 2022, 228:106614.
[37] CHEN Y P, CHENG Y F, WEN C, et al. The protective effects of modified palygorskite on the broilers fed a purified Zearalenone-contaminated diet[J]. Poult Sci, 2019, 98(9):3802–3810.
[38] DING X M, YU Y, SU Z W, et al. Effects of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens[J]. Anim Nutr, 2017, 3(2):127–131.
[39] PERRICONE M, ARACE E, CORBO M R, et al. Bioactivity of essential oils:A review on their interaction with food components[J].Front Microbiol, 2015, 6:76.
[40]中华人民共和国卫生部. GB 29225-2012食品安全国家标准食品添加剂凹凸棒粘土[S].北京:中国标准出版社, 2012.The Ministry of Health of the Ministry of Health of the People’s Republic of China GB 29225-2012 National Food Safety Standard for Food Additives-Attapulgite Clay[S]. Beijing:China Standards Publishing House, 2012.
[41] CHENG H, CHEN J F, TANG S G, et al. Effects of essential oil/palygorskite composite on performance, egg quality, plasma biochemistry, oxidation status, immune response and intestinal morphology of laying hens[J]. Poult Sci, 2022, 101(4):101632.
[42] YANG F F, SONG Y M, HUI A P, et al. Facile preparation of organo-modified ZnO/attapulgite nanocomposites loaded with monoammonium glycyrrhizinate via mechanical milling and their synergistic antibacterial effect[J]. Minerals, 2022, 12(3):364.
[43] ZHANG H, LU Y S, ZHANG Q A, et al. Structural evolution of palygorskite-rich clay as the nanocarriers of silver nanoparticles for efficient improving antibacterial activity[J]. Colloids Surf A Physicochem Eng Aspects, 2022, 652:129885.
[44] LIU J L, GAO Z Y, LIU H, et al. A study on improving the antibacterial properties of palygorskite by using cobalt-doped zinc oxide nanoparticles[J]. Applied Clay Science, 2021, 209:106112.
[45] LIU J L, ZHANG K T, GAO Z Y. Synergistic effect of Ag2S nanoparticles and spiny MoS2 anchored on palygorskite for boosting light-driven antibacterial activity[J]. Colloids Surf A Physicochem Eng Aspects, 2022, 649:129554.
[46] SONG Y M, YANG F F, MA M T, et al. Green synthesized Se–ZnO/attapulgite nanocomposites using Aloe vera leaf extract:Characterization, antibacterial and antioxidant activities[J]. LWT, 2022,165:113762.
[47] ABDULKAREEM M A, JOUDI M S, ALI A H. Eco-friendly synthesis of low-cost antibacterial agent(brown attapulgite-Ag nanocomposite)for environmental application[J]. Chem Data Collect, 2022, 37:100814.
[48] LOBATO-AGUILAR H A, LIZAMA-UC G, URIBE-CALDERON J A,et al. Antibacterial properties and release kinetics of chlorhexidine diacetate from montmorillonite and palygorskite clays[J]. J Biomater Appl, 2020, 34(8):1052–1058.
[49] WU T, XIE A G, TAN S Z, et al. Antimicrobial effects of quaternary phosphonium salt intercalated clay minerals on Escherichia coli and Staphylococci aureus[J]. Colloids Surf B Biointerfaces, 2011, 86(1):232–236.
[50] FENG F, ZHANG X A, MU B, et al. Attapulgite doped with Fe and Cu nanooxides as peroxidase nanozymes for antibacterial coatings[J]. ACS Appl Nano Mater, 2022, 5(11):16720–16730.
[51] JING Y M, MU B, ZHANG M M, et al. Zinc-loaded palygorskite nanocomposites for catheter coating with excellent antibacterial and anti-biofilm properties[J]. 2020, 600:124965.
[52] DONG W K, LU Y S, WANG W B, et al. A sustainable approach to fabricate new 1D and 2D nanomaterials from natural abundant palygorskite clay for antibacterial and adsorption[J]. Chem Eng J, 2020,382:122984.
[53] SU Y, CHEN Y P, CHEN L J, et al. Effects of different levels of modified palygorskite supplementation on the growth performance,immunity, oxidative status and intestinal integrity and barrier function of broilers[J]. J Anim Physiol Anim Nutr, 2018, 102(6):1574–1584.
[54] AALAEI M, KHATIBJOO A, ZAGHARI M, et al. Comparison of single-and multi-strain probiotics effects on broiler breeder performance, egg production, egg quality and hatchability[J]. Br Poult Sci, 2018, 59(5):531–538.
[55] CHALVATZI S, ARSENOS G, TSERVENI-GOUSSI A, et al.Tolerance and efficacy study of palygorskite incorporation in the diet of laying hens[J]. Appl Clay Sci, 2014, 101:643–647.
[56] YU L H, LIU J, MAO J Z, et al. Dietary palygorskite clay-adsorbed nano-ZnO supplementation improves the intestinal barrier function of weanling pigs[J]. Front Nutr, 2022, 9:857898.
[57]毛俊舟,董丽,王淑楠,等.凹土纳米氧化锌对断奶仔猪生长性能、器官指数及血液生化指标的影响[J].动物营养学报, 2018, 30(4):1471–1480.MAO Junzhou, DONG Li, WANG Shunan, et al. Chin J Anim Nutr,2018, 30(4):1471–1480.
[58] YANG W L, CHEN Y P, CHENG Y F, et al. An evaluation of zinc bearing palygorskite inclusion on the growth performance, mineral content, meat quality, and antioxidant status of broilers[J]. Poult Sci,2016, 95(4):878–885.
[59] YAN R, ZHANG L, YANG X, et al. Bioavailability evaluation of zinc-bearing palygorskite as a zinc source for broiler chickens[J]. Appl Clay Sci, 2016, 119:155–160.
[60] YANG J H, LEE J H, RYU H J, et al. Drug–clay nanohybrids as sustained delivery systems[J]. Appl Clay Sci, 2016, 130:20–32.
[61] DIXIT N, MAURYA S D, SAGAR B P. Sustained release drug delivery system[J]. Indian J Res Pharmacy Biotechnol, 2013, 1(3):305.
[62] DING X, ALANI A W, ROBINSON J R. Extended-release and targeted drug delivery systems[M]//The Science and Practice of Pharmacy, Amsterdam:Elsevier, 2006:939?940.
[63] DONG J N, CHENG Z N, TAN S W, et al. Clay nanoparticles as pharmaceutical carriers in drug delivery systems[J]. Expert Opin Drug Deliv, 2021, 18(6):695–714.
[64] CONTE R, DE LUISE A, VALENTINO A, et al. Hydrogel nanocomposite systems[M]//Nanocarriers for Drug Delivery.Amsterdam:Elsevier, 2019:319–349.
[65] DEL CASTILLO CASTRO T, MóNICA M, ORTEGA C, et al.Nanocomposite hydrogels as drug delivery systems[M]//Functional Hydrogels in Drug Delivery. Amsterdam:Elsevier, 2017:24–51.
[66] MOUSA M, EVANS N D, OREFFO R O C, et al. Clay nanoparticles for regenerative medicine and biomaterial design:A review of clay bioactivity[J]. Biomaterials, 2018, 159:204–214.
[67] SORBY D L, LIU G. Effects of adsorbents on drug absorption II[J]. J Pharm Sci, 1966, 55(5):504–510.
[68] STUL M S, VLIERSX D P, UYTTERHOVEN J B. In vitro adsorption-desorption of phenethylamines and phenylimidazoles by a bentonite and a resin[J]. J Pharm Sci, 1984, 73(10):1372–1375.
[69] AGUZZI C, CEREZO P, VISERAS C, et al. Use of clays as drug delivery systems:Possibilities and limitations[J]. Appl Clay Sci, 2007,36(1–3):22–36.
[70] THATIPARTI T R, TAMMISHETTI S, NIVASU M V. UV curable polyester polyol acrylate/bentonite nanocomposites:Synthesis,characterization, and drug release[J]. J Biomed Mater Res, 2010,92B(1):111–119.
[71] YANG H X, WANG W B, ZHANG J P, et al. Preparation,characterization, and drug-release behaviors of a pH-sensitive composite hydrogel bead based on guar gum, attapulgite, and sodium alginate[J]. International Journal Polymeric Materials And Polymeric Biomaterials, 2013, 62(7):369–376.
[72] LI X M, ZHONG H, LI X R, et al. Synthesis of attapulgite/N-isopropylacrylamide and its use in drug release[J]. Mater Sci Eng C Mater Biol Appl, 2014, 45:170–175.
[73] DENG Y Y, XIONG X W, LIU X, et al. Palygorskite combined probiotics improve the laying performance, hatching performance, egg quality, plasma antioxidative status, and immune response of broiler breeders[J]. Ital J Anim Sci, 2021, 20(1):1292–1301.
[74] ZHANG C Z, YAO D W, SU Z N, et al. Copper/zinc-modified palygorskite protects against Salmonella typhimurium infection and modulates the intestinal microbiota in chickens[J]. Front Microbiol,2021, 12:739348.
[75] HUANG W, XIAO Y C, SHI X Y. Construction of electrospun organic/inorganic hybrid nanofibers for drug delivery and tissue engineering applications[J]. Adv Fiber Mater, 2019, 1(1):32–45.
[76] CHOU S F, CARSON D, WOODROW K A. Current strategies for sustaining drug release from electrospun nanofibers[J]. J Control Release, 2015, 220:584–591.
[77] WANG Z, ZHAO Y L, SHEN M W, et al. Antitumor efficacy of doxorubicin-loaded electrospun attapulgite-poly(lactic-co-glycolic acid)composite nanofibers[J]. J Funct Biomater, 2022, 13(2):55.
[78] RODRIGUES L A, FIGUEIRAS A, VEIGA F, et al. The systems containing clays and clay minerals from modified drug release:A review[J]. Colloids Surf B Biointerfaces, 2013, 103:642–651.
[79] XIAO Y X, ZHENG H Y, DU M, et al. Investigation on the potential application of Na-attapulgite as an excipient in domperidone sustained-release tablets[J]. Molecules, 2022, 27(23):8266.
[80]张哲,徐磊,李月,等.一种改性凹凸棒石及其制备方法和在医药载体中的应用[P]. CN110028077B. 2020-09-04.ZHANG Zhe, XU Lei, LI Yue, et al. Modified attapulgite, preparation method thereof and application of modified attapulgite in drug carrier.CN110028077B. 2020-09-04.
[81] NARAYAN R J. Preface[M]//Encyclopedia of Biomedical Engineering.Amsterdam:Elsevier, 2019:374-378.
[82] LANNUTTI J, RENEKER D, MA T, et al. Electrospinning for tissue engineering scaffolds[J]. Mater Sci Eng C, 2007, 27(3):504–509.
[83] Vehof J W M, Haus M T U, De Ruijter A E, et al. Bone formation in Transforming Growth Factor beta-1-loaded titanium fiber mesh implants[J]. Clinical Oral Implants Research, 2002, 13(1):94–102.
[84] WUTTICHAROENMONGKOL P, SANCHAVANAKIT N, PAVASANT P, et al. Preparation and characterization of novel bone scaffolds based on electrospun polycaprolactone fibers filled with nanoparticles[J].Macromol Biosci, 2006, 6(1):70–77.
[85] XIE X R, SHI X Y, WANG S Y, et al. Effect of attapulgite-doped electrospun fibrous PLGA scaffold on pro-osteogenesis and barrier function in the application of guided bone regeneration[J]. Int J Nanomedicine, 2020, 15:6761–6777.
[86] WANG Z, ZHAO Y L, LUO Y, et al. Attapulgite-doped electrospun poly(lactic-co-glycolic acid)nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cells[J]. RSC Adv, 2015,5(4):2383–2391.
[87] KARAGEORGIOU V, KAPLAN D. Porosity of 3D biomaterial scaffolds and osteogenesis[J]. Biomaterials, 2005, 26(27):5474–5491.
[88] DAI T, MA J Y, NI S, et al. Attapulgite-doped electrospun PCL scaffolds for enhanced bone regeneration in rat cranium defects[J].Biomater Adv, 2022, 133:112656.
[89] WANG Z H, HUI A P, ZHAO H B, et al. A novel 3D-bioprinted porous nano attapulgite scaffolds with good performance for bone regeneration[J]. Int J Nanomedicine, 2020, 15:6945–6960.
[90] MATAI I, KAUR G, SEYEDSALEHI A, et al. Progress in 3D bioprinting technology for tissue/organ regenerative engineering[J].Biomaterials, 2020, 226:119536.
[91] LIU C, QIN W, WANG Y, et al. 3D printed gelatin/sodium alginate hydrogel scaffolds doped with nano-attapulgite for bone tissue repair[J].Int J Nanomedicine, 2021, 16:8417–8432.
[92] J?RBRINK K, NI G, S?NNERGREN H, et al. The humanistic and economic burden of chronic wounds:A protocol for a systematic review[J]. Syst Rev, 2017, 6(1):15.
[93] NUSSBAUM S R, CARTER M J, FIFE C E, et al. An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds[J]. Value Health, 2018, 21(1):27–32.
[94] GOIS DA SILVA M L, FORTES A C, OLIVEIRA M E R, et al.Palygorskite organophilic for dermopharmaceutical application[J]. J Therm Anal Calorim, 2014, 115(3):2287–2294.
[95] CAO L H, XIE W J, CUI H Y, et al. Fibrous clays in dermopharmaceutical and cosmetic applications:Traditional and emerging perspectives[J]. Int J Pharm, 2022, 625:122097.
[96] DE GOIS DA SILVA M L, FORTES A C, DA ROCHA TOMéA, et al.The effect of natural and organophilic palygorskite on skin wound healing in rats[J]. Braz J Pharm Sci, 2013, 49(4):729–736.
[97] GARCíA-VILLéN F, SOUZA I M S, DE MELO BARBOSA R, et al.Natural inorganic ingredients in wound healing[J]. Curr Pharm Des,2020, 26(6):621–641.
[98] GARCíA-VILLéN F, SáNCHEZ-ESPEJO R, BORREGO-SáNCHEZ A, et al. Correlation between elemental composition/mobility and skin cell proliferation of fibrous nanoclay/spring water hydrogels[J].Pharmaceutics, 2020, 12(9):891.
[99] MURUGESAN S, SCHEIBEL T. Copolymer/clay nanocomposites for biomedical applications[J]. Adv Funct Materials, 2020, 30(17):1908101.
[100] TENCI M, ROSSI S, AGUZZI C, et al. Carvacrol/clay hybrids loaded into in situ gelling films[J]. Int J Pharm, 2017, 531(2):676–688.
[101] ZHANG Q A, ZHANG H, HUI A P, et al. Synergistic effect of glycyrrhizic acid and ZnO/palygorskite on improving chitosan-based films and their potential application in wound healing[J]. Polymers,2021, 13(22):3878.
[102] WANG X M, MU B, ZHANG H, et al. Incorporation of mixed-dimensional palygorskite clay into chitosan/polyvinylpyrrolidone nanocomposite films for enhancing hemostatic activity[J]. Int J Biol Macromol, 2023, 237:124213.
[103]吕国诚,廖立兵,饶文秀,等.凹凸棒石的资源及应用研究进展[J].矿产保护与利用, 2019, 39(6):112–120.LV Guocheng, LIAO Libing, RAO Wenxiu, et al. Conserv Util Miner Resour(in Chinese), 2019, 39(6):112–120.
[104] KATTI K S, JASUJA H, KAR S, et al. Nanostructured biomaterials for in vitro models of bone metastasis cancer[J]. Curr Opin Biomed Eng,2021, 17:100254.
[105] KATTI K S, JASUJA H, JASWANDKAR S V, et al. Nanoclays in medicine:A new frontier of an ancient medical practice[J]. Mater Adv,2022, 3(20):7484–7500.
基本信息:
DOI：10.14062/j.issn.0454-5648.20230419
中图分类号:TB383.1;R318.08
引用信息:
[1]孙伟,王申金,刘小溪,等.凹凸棒石在生物医学领域中的应用研究进展[J].硅酸盐学报,2024,52(01):359-370.DOI:10.14062/j.issn.0454-5648.20230419.
基金信息:
2023年中南大学创新驱动计划(2023CXQD002); 国家自然科学基金青年项目(82301063); 南京南欣医药技术研究院横向(738010434); 长沙市科技计划(杰出创新青年培养计划,kq2106016)
2023-06-18
2023
2023-11-29
2023
2023-11-29
1
2023-12-14
2023-12-14
2023-12-14