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2023, 10, v.51 2553-2565
微纳米生物活性玻璃的制备与应用
基金项目(Foundation): 国家自然科学基金(32000933,32171311,U1501245,51672088)
邮箱(Email): chenxf@scut.edu.cn;
DOI: 10.14062/j.issn.0454-5648.20230200
发布时间: 2023-08-04
出版时间: 2023-08-04
网络发布时间: 2023-08-04
移动端阅读
摘要:

微纳米生物活性玻璃(MNBG)已被证明具有良好的生物活性,在骨、齿及皮肤创面修复及组织工程领域受到高度关注。在近些年的研究中,多种金属离子在MNBG的制备过程中被掺入材料的网络结构中,从而赋予MNBG各种理化及生物学功能特性。然而,MNBG的离子释放产物与人体细胞之间相互作用的确切机制尚不完全清楚,这促使国内外研究者对离子掺杂的MNBG进行了较深入的研究。本文综述了有关MNBG的制备方法和工艺流程及其溶解产物在骨、齿等硬组织修复,皮肤组织修复,癌症治疗及细胞成像等方面的应用。为进一步开发应用于生物医学领域的新型MNBG提供参考。

Abstract:

Micro-nano bioactive glass(MNBG) has a good biological activity and is widely used in tissue engineering. In recent years, a variety of metal ions are incorporated into the network structure of materials during the preparation of MNBG, thereby endowing MNBG with various physicochemical and biological functional properties. However, the exact mechanism of interaction between the ion release products of MNBG and human cells is not fully clarified. This review represented the preparation methods and processes of MNBG and the application of its lysates in bone and tooth and other hard tissue repair, skin tissue repair, cancer treatment and cell imaging. This review could provide a reference for the further development of MNBGs applied to the biomedical field.

参考文献

[1] BOCCACCINI A R, BRAUER D S, HUPA L. Bioactive glasses:Fundamentals, technology and applications[M]. Cambridge:Royal Society of Chemistry, 2016.

[2] KIM J J, EL-FIQI A, KIM H W. Synergetic cues of bioactive nanoparticles and nanofibrous structure in bone scaffolds to stimulate osteogenesis and angiogenesis[J]. ACS Appl Mater Interfaces, 2017,9(3):2059–2073.

[3]王聿栋.用于药物载体的介孔生物活性玻璃的乳液法制备及其性能研究[D].广州:华南理工大学.WANG Yudong. Emulsion preparation and characterization of mesoporous bioactive glasses for drug delivery(in Chinese,dissertation). Guangzhou:South China University of Technology.

[4] KARGOZAR S, BAINO F, HAMZEHLOU S, et al. Bioactive glasses:sprouting angiogenesis in tissue engineering[J]. Trends Biotechnol,2018, 36(4):430–444.

[5]陈晓峰,常江.生物活性玻璃[M].北京:科学出版社, 2022.

[6] ZHANG W, ZHAO F J, HUANG D Q, et al. Strontium-substituted submicrometer bioactive glasses modulate macrophage responses for improved bone regeneration[J]. ACS Appl Mater Interfaces, 2016,8(45):30747–30758.

[7] ZHAO F J, LEI B, LI X, et al. Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes[J]. Biomaterials, 2018,178:36–47.

[8] LUO M, ZHAO F J, LIU L, et al. IFN-γ/SrBG composite scaffolds promote osteogenesis by sequential regulation of macrophages from M1 to M2[J]. J Mater Chem B, 2021, 9(7):1867–1876.

[9] SHI M, ZHAO F J, SUN L Y, et al. Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis[J]. Mater Sci Eng C Mater Biol Appl, 2021, 124:112077.

[10] YANG Z, ZHAO F J, ZHANG W, et al. Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects:From anti-tumor to repairing bone defects[J]. Chem Eng J, 2021, 419:129520.

[11] THOMPSON K H, ORVIG C. Boon and bane of metal ions in medicine[J]. Science, 2003, 300(5621):936–939.

[12] HOPPE A, GüLDAL N S, BOCCACCINI A R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics[J]. Biomaterials, 2011, 32(11):2757–2774.

[13]杨宇霞,王迎军,陈晓峰,等.微乳法制备条件对Ca O–P2O5–SiO2系统生物活性纳米粒子形貌和粒径分布的影响[C]//中国生物医学工程学会第六次会员代表大会暨学术会议论文摘要汇编.武汉,2004:136.

[14] BRUNNER T J, GRASS R N, STARK W J. Glass and bioglass nanopowders by flame synthesis[J]. Chem Commun, 2006(13):1384–1386.

[15]陈晓峰,翁杰.生物医学材料学性能与制备[M].北京:人民卫生出版社, 2021.

[16] ZHENG K, LU M, RUTKOWSKI B, et al. ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties[J]. J Mater Chem B, 2016, 4(48):7936–7949.

[17] TSIGKOU O, LABBAF S, STEVENS M M, et al. Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells[J]. Adv Healthc Mater, 2014,3(1):115–125.

[18]胡庆.用于牙髓损伤修复的新型微纳米生物活性玻璃的仿生制备及性能研究[D].广州:华南理工大学, 2014.HU Qing. Biomimetic preparation and characterization of the novel micro/nano-bioactive glasses for pulp repair(in Chinese, dissertation).Guangzhou:South China University of Technology, 2014.

[19]梁绮明.新型生物玻璃牙髓修复材料的制备与性能研究[D].广州:华南理工大学, 2015.LIANG Qiming. Preparation and characterization of novel bioglass material for dental pulp repair(in Chinese, dissertation). Guangzhou:South China University of Technology, 2015.

[20] DE OLIVEIRA A A R, DE SOUZA D A, DIAS L L S, et al. Synthesis,characterization and cytocompatibility of spherical bioactive glass nanoparticles for potential hard tissue engineering applications[J].Biomed Mater, 2013, 8(2):025011.

[21]苗国厚.用于药物及基因载体研究的介孔生物活性玻璃的制备及其性能研究[D].广州:华南理工大学, 2014.MIAO Guohou. Research on the preparation and characterization of mesoporous bioactive glasses for drug and gene delivery system(in Chinese, dissertation). Guangzhou:South China University of Technology, 2014.

[22] MARTíNEZ A, IZQUIERDO-BARBA I, VALLET-REGíM.Bioactivity of a CaO–SiO2 binary glasses system[J]. Chem Mater, 2000,12(10):3080–3088.

[23] SALTMAN P D, STRAUSE L G. The role of trace minerals in osteoporosis[J]. J Am Coll Nutr, 1993, 12(4):384–389.

[24] BEATTIE J H, AVENELL A. Trace element nutrition and bone metabolism[J]. Nutr Res Rev, 1992, 5(1):167–188.

[25] O’DONNELL S, CRANNEY A, WELLS G A, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis[J]. Cochrane Database Syst Rev, 2006(3):CD005326.

[26] HUANG M, HILL R G, RAWLINSON S C F. Strontium(Sr)elicits odontogenic differentiation of human dental pulp stem cells(hDPSCs):A therapeutic role for Sr in dentine repair?[J]. Acta Biomater, 2016, 38:201–211.

[27] BONNELYE E, CHABADEL A, SALTEL F, et al. Dual effect of strontium ranelate:Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro[J]. Bone,2008, 42(1):129–138.

[28] LIU J, RAWLINSON S C, HILL R G, et al. Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects[J]. Dent Mater, 2016, 32(3):412–422.

[29] SCHINDELER A, LITTLE D G. Ras-MAPK signaling in osteogenic differentiation:Friend or foe?[J]. J Bone Miner Res, 2006, 21(9):1331–1338.

[30] YANG F, YANG D Z, TU J E, et al. Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling[J]. Stem Cells, 2011, 29(6):981–991.

[31] CHEN Y, WHETSTONE H C, LIN A C, et al. Beta-catenin signaling plays a disparate role in different phases of fracture repair:Implications for therapy to improve bone healing[J]. PLoS Med, 2007, 4(7):e249.

[32] VERBERCKMOES S C, DE BROE M E, D’HAESE P C.Dose-dependent effects of strontium on osteoblast function and mineralization[J]. Kidney Int, 2003, 64(2):534–543.

[33] GENTLEMAN E, FREDHOLM Y C, JELL G, et al. The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro[J]. Biomaterials, 2010, 31(14):3949–3956.

[34]张文.掺锶亚微米生物活性玻璃促进骨修复的机制研究[D].广州:华南理工大学, 2017.ZHANG Wen. Research on mechanism of strontium-substituted sub-micron bioactive glasses for improved bone repair(in Chinese,dissertation). Guangzhou:South China University of Technology,2017.

[35] ZHAO S C, LI L, WANG H, et al. Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model[J]. Biomaterials,2015, 53:379–391.

[36] EROL M M, MOURI?O V, NEWBY P, et al. Copper-releasing,boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering[J]. Acta Biomater, 2012, 8(2):792–801.

[37] CHITRA S, BARGAVI P, BALASUBRAMANIAM M, et al. Impact of copper on in-vitro biomineralization, drug release efficacy and antimicrobial properties of bioactive glasses[J]. Mater Sci Eng C Mater Biol Appl, 2020, 109:110598.

[38] ROMERO-SáNCHEZ L B, MARí-BEFFA M, CARRILLO P, et al.Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model[J]. Acta Biomater, 2018, 68:272–285.

[39] RYAN E J, RYAN A J, GONZáLEZ-VáZQUEZ A, et al. Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo[J]. Biomaterials, 2019, 197:405–416.

[40] SKALLEVOLD H E, ROKAYA D, KHURSHID Z, et al. Bioactive glass applications in dentistry[J]. Int J Mol Sci, 2019, 20(23):5960.

[41] IVIGLIA G, KARGOZAR S, BAINO F. Biomaterials, current strategies, and novel nano-technological approaches for periodontal regeneration[J]. J Funct Biomater, 2019, 10(1):3.

[42] EL-FIQI A, MANDAKHBAYAR N, JO S B, et al. Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity[J].Bioact Mater, 2021, 6(1):123–136.

[43] XIAO J S, ZHU Y X, HUDDLESTON S, et al. Copper metal–organic framework nanoparticles stabilized with folic acid improve wound healing in diabetes[J]. ACS Nano, 2018, 12(2):1023–1032.

[44] XIAO J S, CHEN S Y, YI J, et al. A cooperative copper metal-organic framework-hydrogel system improves wound healing in diabetes[J].Adv Funct Mater, 2017, 27(1):1604872.

[45] WANG X J, CHENG F, LIU J, et al. Biocomposites of copper-containing mesoporous bioactive glass and nanofibrillated cellulose:Biocompatibility and angiogenic promotion in chronic wound healing application[J]. Acta Biomater, 2016, 46:286–298.

[46] PHILIPS N, SAMUEL P, PARAKANDI H, et al. Beneficial regulation of fibrillar collagens, heat shock protein-47, elastin fiber components,transforming growth factor-β1, vascular endothelial growth factor and oxidative stress effects by copper in dermal fibroblasts[J]. Connect Tissue Res, 2012, 53(5):373–378.

[47] LI J Y, ZHAI D, LV F, et al. Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis,antibacterial activity and wound healing[J]. Acta Biomater, 2016, 36:254–266.

[48] HESSEL C M, PATTANI V P, RASCH M, et al. Copper selenide nanocrystals for photothermal therapy[J]. Nano Lett, 2011, 11(6):2560–2566.

[49] LI K C, CHU H C, LIN Y, et al. PEGylated copper nanowires as a novel photothermal therapy agent[J]. ACS Appl Mater Interfaces, 2016,8(19):12082–12090.

[50] LIU K, LIU K, LIU J C, et al. Copper chalcogenide materials as photothermal agents for cancer treatment[J]. Nanoscale, 2020, 12(5):2902–2913.

[51] YU Q Q, HAN Y M, WANG X C, et al. Copper silicate hollow microspheres-incorporated scaffolds for chemo-photothermal therapy of melanoma and tissue healing[J]. ACS Nano, 2018, 12(3):2695–2707.

[52] CACCIOTTI I. Bivalent cationic ions doped bioactive glasses:The influence of magnesium, zinc, strontium and copper on the physical and biological properties[J]. J Mater Sci, 2017, 52(15):8812–8831.

[53] BALAMURUGAN A, BALOSSIER G, KANNAN S, et al.Development and in vitro characterization of sol?gel derived Ca O–P2O5–SiO2–ZnO bioglass[J]. Acta Biomater, 2007, 3(2):255–262.

[54] NE??áKOVáZ, ZHENG K, LIVERANI L, et al. Multifunctional zinc ion doped sol?gel derived mesoporous bioactive glass nanoparticles for biomedical applications[J]. Bioact Mater, 2019, 4:312–321.

[55] PéREZ R, SANCHEZ-SALCEDO S, LOZANO D, et al. Osteogenic effect of ZnO-mesoporous glasses loaded with osteostatin[J].Nanomaterials, 2018, 8(8):592.

[56] ZHAO R, SHI L F, GU L, et al. Evaluation of bioactive glass scaffolds incorporating SrO or ZnO for bone repair:In vitro bioactivity and antibacterial activity[J]. J Appl Biomater Funct Mater, 2021, 19:22808000211040910.

[57] ATKINSON I, ANGHEL E M, PREDOANA L, et al. Influence of ZnO addition on the structural, in vitro behavior and antimicrobial activity of sol?gel derived CaO–P2O5–SiO2 bioactive glasses[J]. Ceram Int,2016, 42(2):3033–3045.

[58] PUNJ S, SINGH J, SINGH K. Ceramic biomaterials:Properties, state of the art and future prospectives[J]. Ceram Int, 2021, 47(20):28059–28074.

[59] BAI X, LIU W J, XU L J, et al. Sequential macrophage transition facilitates endogenous bone regeneration induced by Zn-doped porous microcrystalline bioactive glass[J]. J Mater Chem B, 2021, 9(12):2885–2898.

[60] BOSE S, FIELDING G, TARAFDER S, et al. Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics[J]. Trends Biotechnol, 2013, 31(10):594–605.

[61] KARGOZAR S, MILAN P B, AMOUPOUR M, et al. Osteogenic potential of magnesium(Mg)-doped multicomponent bioactive glass:In vitro and in vivo animal studies[J]. Materials, 2022, 15(1):318.

[62] SUN Y, LIN J, LI L L, et al. In vitro and in vivo study of magnesium containing bioactive glass nanoparticles modified gelatin scaffolds for bone repair[J]. Biomed Mater, 2022, 17(2):025018.

[63] SCHROEDER H A, TIPTON I H, NASON A P. Trace metals in man:Strontium and Barium[J]. J Chronic Dis, 1972, 25(9):491–517.

[64] YAZDANPANAH A, MOZTARZADEH F. Synthesis and characterization of barium-iron containing magnetic bioactive glasses:The effect of magnetic component on structure and in vitro bioactivity[J]. Colloids Surf B Biointerfaces, 2019, 176:27–37.

[65] BIZARI D, YAZDANPANAH A, MOZTARZADEH F. Ba O–Fe2O3containing bioactive glasses:A potential candidate for cancer hyperthermia[J]. Mater Chem Phys, 2020, 241:122439.

[66] MAJUMDAR S, HIRA S K, TRIPATHI H, et al. Synthesis and characterization of barium-doped bioactive glass with potential anti-inflammatory activity[J]. Ceram Int, 2021, 47(5):7143–7158.

[67] VADERA N, ASHOKAN A, GOWD G S, et al. Manganese doped nano-bioactive glass for magnetic resonance imaging[J]. Mater Lett,2015, 160:335–338.

[68] NAWAZ Q, REHMAN M A U, BURKOVSKI A, et al. Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications[J]. J Mater Sci Mater Med,2018, 29(5):1–13.

[69] WESTHAUSER F, WILKESMANN S, NAWAZ Q, et al. Effect of manganese, zinc, and copper on the biological and osteogenic properties of mesoporous bioactive glass nanoparticles[J]. J Biomed Mater Res, 2021, 109(8):1457–1467.

[70] WESTHAUSER F, WILKESMANN S, NAWAZ Q, et al. Osteogenic properties of manganese-doped mesoporous bioactive glass nanoparticles[J]. J Biomed Mater Res A, 2020, 108(9):1806–1815.

[71] RAYMAN M P. Selenium and human health[J]. Lancet, 2012,379(9822):1256–1268.

[72] AMARAL A F S, PORTA M, SILVERMAN D T, et al. Pancreatic cancer risk and levels of trace elements[J]. Gut, 2012, 61(11):1583–1588.

[73] WANG X, ZHANG Y, MA Y Y, et al. Selenium-containing mesoporous bioactive glass particles:Physicochemical and drug delivery properties[J]. Ceram Int, 2016, 42(2):3609–3617.

[74] HU M, FANG J, ZHANG Y, et al. Design and evaluation a kind of functional biomaterial for bone tissue engineering:Selenium/mesoporous bioactive glass nanospheres[J]. J Colloid Interface Sci, 2020, 579:654–666.

[75] PALZA H, ESCOBAR B, BEJARANO J, et al. Designing antimicrobial bioactive glass materials with embedded metal ions synthesized by the sol?gel method[J]. Mater Sci Eng C Mater Biol Appl, 2013, 33(7):3795–3801.

[76] EL-RASHIDY A A, WALY G, GAD A, et al. Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol?gel process and modified St?ber method[J]. J Non Cryst Solids, 2018, 483:26–36.

[77] DIZAJ S M, LOTFIPOUR F, BARZEGAR-JALALI M, et al.Antimicrobial activity of the metals and metal oxide nanoparticles[J].Mater Sci Eng C Mater Biol Appl, 2014, 44:278–284.

[78] TAUTKUS S, ISHIKAWA K, RAMANAUSKAS R, et al. Zinc and chromium co-doped calcium hydroxyapatite:Sol?gel synthesis,characterization, behaviour in simulated body fluid and phase transformations[J]. J Solid State Chem, 2020, 284:121202.

[79] BRENNAN S A, FHOGHLúC N, DEVITT B M, et al. Silver nanoparticles and their orthopaedic applications[J]. Bone Joint J, 2015,97-B(5):582–589.

[80] GHOSH R, DAS S, MALLICK S P, et al. A review on the antimicrobial and antibiofilm activity of doped hydroxyapatite and its composites for biomedical applications[J]. Mater Today Commun,2022, 31:103311.

[81] GODOY-GALLARDO M, ECKHARD U, DELGADO L M, et al.Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications[J]. Bioact Mater,2021, 6(12):4470–4490.

[82] SHI C, GAO J Y, WANG M, et al. Ultra-trace silver-doped hydroxyapatite with non-cytotoxicity and effective antibacterial activity[J]. Mater Sci Eng C, 2015, 55:497–505.

[83] ZHANG Y, HU M, WANG X, et al. Design and evaluation of europium containing mesoporous bioactive glass nanospheres:Doxorubicin release kinetics and inhibitory effect on osteosarcoma MG 63 cells[J].Nanomaterials, 2018, 8(11):961.

[84] HUANG S S, KANG X J, CHENG Z Y, et al. Electrospinning preparation and drug delivery properties of Eu3+/Tb3+doped mesoporous bioactive glass nanofibers[J]. J Colloid Interface Sci, 2012,387(1):285–291.

[85] XUE Y M, DU Y Z, YAN J, et al. Monodisperse photoluminescent and highly biocompatible bioactive glass nanoparticles for controlled drug delivery and cell imaging[J]. J Mater Chem B, 2015, 3(18):3831–3839.

[86] SHI M C, XIA L G, CHEN Z T, et al. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent[J]. Biomaterials, 2017, 144:176–187.

[87] DE SIQUEIRA L, CAMPOS T M B, CAMARGO S E A, et al.Structural, crystallization and cytocompatibility evaluation of the 45S5bioglass-derived glass-ceramic containing niobium[J]. J Non Cryst Solids, 2021, 555:120629.

[88] BALBINOT G S, LEITUNE V C B, PONZONI D, et al. Bone healing with niobium-containing bioactive glass composition in rat femur model:A micro-CT study[J]. Dent Mater, 2019, 35(10):1490–1497.

[89] ZHAO F J, YANG Z, XIONG H C, et al. A bioactive glass functional hydrogel enhances bone augmentation via synergistic angiogenesis,self-swelling and osteogenesis[J]. Bioact Mater, 2023, 22:201–210.

[90] Bronner F. Chapter 25-Metals in Bone:Aluminum, Boron, Cadmium,Chromium, Lanthanum, Lead, Silicon, and Strontium[M]//BILEZIKIAN J P, RAISZ L G, MARTIN T J. Principles of Bone Biology(3rd Ed). San Diego; Academic Press. 2008:515–31.

[91] ZHU D Y, LU B, YANG Q H, et al. Lanthanum-doped mesoporous bioglasses/chitosan composite scaffolds enhance synchronous osteogenesis and angiogenesis for augmented osseous regeneration[J].Chem Eng J, 2021, 405:127077.

[92] EL-MELIEGY E, FARAG M M, EL-KADY A M, et al. Evaluation of solubility and cytotoxicity of lanthanum-doped phosphate glasses nanoparticles for drug delivery applications[J]. J Non Cryst Solids,2017, 475:59–70.

[93] YAMAGATA N. The concentration of common cesium and rubidium in human body[J]. J Radiat Res, 1962, 3:9–30.

[94] OUYANG S H, ZHENG K, HUANG Q L, et al. Synthesis and characterization of rubidium-containing bioactive glass nanoparticles[J]. Mater Lett, 2020, 273:127920.

[95] CELARDO I, PEDERSEN J Z, TRAVERSA E, et al. Pharmacological potential of cerium oxide nanoparticles[J]. Nanoscale, 2011, 3(4):1411–1420.

[96] MAHAPATRA C, SINGH R K, LEE J H, et al. Nano-shape varied cerium oxide nanomaterials rescue human dental stem cells from oxidative insult through intracellular or extracellular actions[J]. Acta Biomater, 2017, 50:142–153.

[97] NAGANUMA T, TRAVERSA E. The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation[J].Biomaterials, 2014, 35(15):4441–4453.

[98] NETHI S K, NANDA H S, STEELE T W J, et al. Functionalized nanoceria exhibit improved angiogenic properties[J]. J Mater Chem B,2017, 5(47):9371–9383.

[99] ZHENG K, TORRE E, BARI A, et al. Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities[J]. Mater Today Bio, 2020, 5:100041.

基本信息:

DOI:10.14062/j.issn.0454-5648.20230200

中图分类号:TQ171.7;R318.08

引用信息:

[1]杨峥宇,赵夫健,杜昶,等.微纳米生物活性玻璃的制备与应用[J].硅酸盐学报,2023,51(10):2553-2565.DOI:10.14062/j.issn.0454-5648.20230200.

基金信息:

国家自然科学基金(32000933,32171311,U1501245,51672088)

发布时间:

2023-08-04

出版时间:

2023-08-04

网络发布时间:

2023-08-04

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