| 1,742 | 37 | 58 |
| 下载次数 | 被引频次 | 阅读次数 |
本文综述羟基磷灰石(hydroxyapatite,HA)生物陶瓷材料的研究进展,通过调控HA形貌以优化其使用性能。用不同方法制备多孔HA,旨在强化骨传导性和诱导性,同时能实现骨的增强与增韧。设计HA复合材料以弥补单一HA力学性能的不足。从仿生学角度提出HA的研究趋势:合成具有类似于自然骨精细结构的仿生学骨组织材料,实现HA生物陶瓷材料与有机体力学相容性和生物相容性尽可能理想地匹配。
Abstract:A review of progress in hydroxyapatite (HA) bioceramic materials is presented in this paper. The functional performance of HA can be optimized through tailoring its morphology. Porous HA ceramics prepared by various methods have strong abilities to in-tensify the osteoconduction and osteoinduction,and to improve the strength and toughness. HA composite materials can counteract the weaknesses of mechanical property of pure HA. The research trend of HA is discussed in terms of bionics. It is shown that synthe-sizing bionic bone materials with fine structure similar to natural bone can maximize the mechanical compatibility and biocompatibility between HA bioceramic materials and organisms.
[1]SOPYAN I,MEL M,RAMESH S,et al.Porous hydroxyapatite for artificial bone applications[J].Sci Technol Adv Mater,2007,8(1):116–123.
[2]BUCHOLZ RW.Nonallograft osteoconductive bone graft substitutes[J].Clin Orthop Relat Res,2002,(395):44–52.
[3]SUCHANEK W,YOSHIMURA M.Processing and properties of hy-droxyapatite-based biomaterials for use as hard tissue replacement im-plants[J].J Mater Res,1998,13(1):94–117.
[4]MURRAY M G S,WANG J,PONTON C B,et al.An improvement in processing of hydroxyapatite ceramics[J].J Mater Sci,1995,30(12):3061–3071.
[5]GAO Weimin,RUAN Chengxiang,CHEN Yunfa.Effects of acidic amino acids on hydroxyapatite morphology[J].Key Eng Mater,2007,336(part3):2096–2099.
[6]RIPAMNTI U,CROOKS J,KIRKBRIDE A N.Sintered porous hy-droxyapatites with intrinsic osteoinductive activity:geometric induc-tion of bone formation[J].S Afr J Sci,1999,85(8):335–348.
[7]FUJISHIRO Y,YABUKI H,KAWAMURA K,et al.Preparation of needle-like hydroxyapatite by homogeneous precipitation under hydrothermal conditions[J].J Chem Technol Biotechnol,1993,57(4):349–353.
[8]黄立业,徐可为.纳米针状羟基磷灰石涂层的制备及其性能的研究[J].硅酸盐学报,1999,27(3):351–356.HUANG Liye,XU Kewei.J Chin Ceram Soc(in Chinese),1999,27(3):351–356.
[9]CAO Liyun,ZHANG Chuanbo,HUANG Jianfeng.Synthesis of hy-droxyapatite nanoparticles in ultrasonic precipitation[J].Ceram Int,2005,31(8):1041–1044.
[10]郭大刚,付涛,徐可为.短棒状纳米羟基磷灰石的湿法合成及表征[J].硅酸盐学报,2002,30(2):190–192.GUO Dagang,FU Tao,XU Kewei.J Chin Ceram Soc(in Chinese),2002,30(2):190–192.
[11]刘敬肖,史非,周靖,等.模拟体液中仿生羟基磷灰石超细粉的制备及表征[J].硅酸盐学报,2006,34(3):334–339.LIU Jingxiao,SHI Fei,ZHOU Jing,et al.J Chin Ceram Soc(in Chi-nese),2006,34(3):334–339.
[12]彭继荣,李珍,刘明阳,等.羟基磷灰石的湿法制备及其对F–的吸附特性[J].环境科学与技术,2005,28(4):33–36.PENG Jirong,LI Zhen,LIU Mingyang,et al.Environ Sci Technol(in Chinese),2005,28(4):33–36.
[13]QIU C F,XIAO X F,LIU R F,et al.Biomimetic synthesis of spherical nano-hydroxyapatite with polyvinylpyrrolidone as template[J].Mater Sci Tech,2008,24(5):612–617.
[14]QIU Chaofan,XIAO Xiufeng,LIU Rongfang.Biomimetic synthesis of spherical nano-hydroxyapatite in the presence of polyethylene glycol[J].Ceram Int,2008,34(7):1747–1751.
[15]刘芳,肖秀峰,刘榕芳.以聚苯乙烯磺酸钠为模板合成球状羟基磷灰石[J].化工时刊,2008,22(8):18–21.LIU Fang,XIAO Xiufeng,LIU Rongfang.Chem Ind Times(in Chi-nese),2008,22(8):18–21.
[16]WEINER S,PRICE P A.Disaggregation of bone into crystals[J].Calcif Tissue Int,1986,39(5):365–375.
[17]ASHOK M,SUNDARAM N M,KALKURA S N.Crystallization of hydroxyapatite at physiological temperature[J].Mater Lett,2003,57(13):2066–2070.
[18]GAO Weimin,LI Qunyan,RUAN Chengxiang,et al.Morphology tailoring of hydroxyapatite nanoparticles by hydrothermal processing with amino acids[J].Key Eng Mater,2005,280(part2):1533–1536.
[19]BERMAN A,HANSON J,LEISEROWITZ L,et al.Biological control of crystal texture:a widespread strategy for adapting crystal properties to function[J].Science,1993,259:776.
[20]黄志良,刘羽,王大伟,等.胶原蛋白模板诱导片状纳米羟基磷灰石(HA)的仿生合成[J].材料导报,2002,16(10):69–71.HUANG Zhiliang,LIU Yu,WANG Dawei,et al.Mater Rev(in Chi-nese),2002,16(10):69–71.
[21]XIAO Xiufeng,HE Dan,LIU Fang,et al.Preparation and characteriza-tion of hydroxyapatite/chondroitin sulfate composites by biomimetic synthesis[J].Mater Chem Phys,2008,112(3):838–843.
[22]SHOR L,GUCERI S,WEN X,et al.Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro[J].Biomater,2007,28(35):5291–5297.
[23]XU H H K,BURGUERA E F,CAREY L E.Strong,macroporous,and in situ-setting calcium phosphate cement-layered structures[J].Bio-mater,2007,28(26):3786–3796.
[24]SUN Ruixue,LU Yupeng.Fabrication and characterization of porous hydroxyapatite microspheres by spray-drying method[J].Front Mater Sci China,2008,2(1):95–98.
[25]YANG Lei,NING Xiaoshan,CHEN Kexin.Preparation of porous hydroxyapatite ceramics with starch additives[J].Trans Nonferrous Met Soc China,2005,15(2):257–260.
[26]COSTAS Tsioptsias,LOANNIS Tsivintzelis,LAMBRINI Papadopou-lou.A novel method for producing tissue engineering scaffolds from chitin,chitin–hydroxyapatite,and cellulose[J].Mater Sci Eng:C,2009,29(1):159–164.
[27]SONG Ho-Yeon,ISLAM Shamiul,LEE Byong-Taek.A Novel method to fabricate unidirectional porous hydroxyapatite body using ethanol bubbles in a viscous slurry[J].J Am Ceram Soc,2008,91(9):3125–3127.
[28]DONG Zhihong,LI,Yubao,ZOU Qin.Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering[J].Appli Surf Sci,2009,255(12):6087–6091.
[29]WANG L,LI Y,ZUO Y,et al.Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regeneration[J].Biomed Mater,2009,4(2):1–7.
[30]IVANKOVIC H,GALLEGO F G,TKALCEC E,et al.Preparation of highly porous hydroxyapatite from cuttlefish bone[J].J Mater Sci Mater Med,2009,20(5):1039–1046.
[31]ZHOU Liyun,WANG Deping,HUANG Wenhai,et al.Fabrication of hydroxyapatite with highly ordered macroporous frame by colloidal templating method[J].Mater Res Bull,2009,44(2):259–262.
[32]赵康,魏俊琪,罗德福,等.冷冻干燥法制备羟基磷灰石多孔支架[J].硅酸盐学报,2009,37(3):432–435.ZHAO Kang,WEI Junqi,LUO Defu.J Chin Ceram Soc(in Chinese),2009,37(3):432–435.
[33]ZHANG Y,TANNER K.Effect of filler surface morphology on the impact behavior of hydroxyapatite reinforced high density polyethylene composites[J].J Mater Sci Mater Med,2008,19(2):761–766.
[34]WEI Jie,LI Yubao,CHEN Weiqun.A study on nano-composite of hydroxyapatite and polyamide[J].J Mater Sci,2003,38(15):3303–3306.
[35]YANG C,CHENG K,WENG W,et al.OTS-modified HA and its toughening effect on PLLA/HA porous composite[J].J Mater Sci Mater Med,2009,20(3):667–672.
[36]苏佳灿,李明,禹宝庆,等.纳米羟基磷灰石/聚己内酯复合生物活性多孔支架研究[J].无机材料学报,2009,24(3):485–490.SU Jiacan,LI Ming,YU Baoqing,et al.J Inorg Mater(in Chinese),2009,24(3):485–490.
[37]HUANG X,MIAO X.Novel porous hydroxyapatite prepared by combining H2O2foaming with PU sponge and modified with PLGA and bioactive glass[J].J Biomater Appl,2007,21(4):351–374.
[38]KIKUCHI M,IKOMA T,MATSUMOTO H N,et al.Biomimetic synthesis of bone-like nanocomposites using the self-organization mechanism of hydroxyapatite and collagen[J].Compos Sci Technol,2004,64(6):819–825.
[39]TENG S,CHEN L,GUO Y,el al.Formation of nano-hydroxyapatite in gelatin droplets and the resulting porous composite microsphercs[J].J Inorg Biochem,2007,10l(4):686–69l.
[40]JIANG L Y,LI Y B,XIONG C D.Preparation and biological properties of a novel composite scaffold of nano-hydroxyapatite/chitosan/car-boxymethyl cellulose for bone tissue engineering[J].J Biomed Sci,2009,16(1):65–75.
[41]KARIM A,FARIBA O,FATHOLLAH M.Fabrication and characteri-zation of a porous composite scaffold based on gelatin and hydroxya-patite for bone tissue engineering[J].Iran Poly J,2005,14(5):511–520.
基本信息:
DOI:10.14062/j.issn.0454-5648.2010.06.012
中图分类号:TQ174.79
引用信息:
[1]孙艳荣,范涛,黄勇,等.羟基磷灰石生物陶瓷材料的研究趋势及展望[J].硅酸盐学报,2010,38(06):1145-1150.DOI:10.14062/j.issn.0454-5648.2010.06.012.
基金信息:
清华大学新型陶瓷与精细工艺国家重点实验室开放课题(KF09011);; 北华航天工业学院科研基金(KY–2009–01–B)资助项目
2010-06-15
2010-06-15